TRPV1

瞬态感受器阳离子电压通道
子分类V，成员1 *[人类]*
瞬态感受器阳离子电压通道; 子分类V，成员1 [人类]
	TRPV1离子通道同源蛋白四聚体的结构模型，其中每一个单体用青、绿、蓝及洋红色分别标出。其中的4,5-二磷酸基磷脂酰肌醇触发配体，根据空间填充模型分别用白、红、橙三种颜色代表碳、氧及磷原子。其周围的黄色部分为该通道所嵌入其中的双脂膜的示意情形。
标识
代号	TRPV1; DKFZp434K0220; VR1
扩展标识	遗传学：602076 鼠基因：1341787 同源基因：12920 IUPHAR: TRPV1 GeneCards: TRPV1 Gene
基因本体论描述
分子功能	· 感受器活动; · 离子通道活动; · 钙离子通道活动; · 钙离子结合; · 钙调蛋白结合; · 阳离子跨膜转运活动;
细胞成分	· 嵌入质膜; · 膜; · 嵌入膜;
生物过程	· 体温调节; · 离子转运; · 钙离子转运; · 细胞表面感受器信号转换; · 化学感受器行为; · 酸碱度响应; · 热感响应; · 痛觉感受器; · 温度感应;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	7442
Ensembl	ENSG00000196689
UniProt	Q8NER1
mRNA序列	NM_018727
蛋白序列	NP_061197
基因位置	Chr 17:; 3.42 – 3.45 Mb
PubMed查询	[1]
	查; 论; 编;

TRPV1是指“瞬态感受器电位阳离子通道，子类V，成员1”（transient receptor potential cation channel, subfamily V, member 1），该通道是一个蛋白质，在人类基因中由TRPV1基因所编码^[2]^[3]。这一通道属于一种离子通道，是瞬态电压感受器族中的一员，属于TRPV组（即瞬态感受器电位阳离子通道，子类V）^[4]。

TRPV1是一个配体门控非选择性阳离子通道，可以被各种外因性及内因性的物理及化学刺激所激发，例如：温度超过43 °C、pH值低（酸性环境）、内源性大麻素花生四烯酸乙醇胺、N-花生四烯酰基多巴胺以及辣椒素（辣椒的有效成分）。这一通道被发现存在于中枢神经系统及末梢神经系统上，并且涉及痛觉的传递和调制，以及整合各种同疼痛信息^[5]^[6]。

^ Brauchi, Sebastian; Orta, Gerardo; Mascayano, Carolina; Salazar, Marcelo; Raddatz, Natalia; Urbina, Hector; Rosenmann, Eduardo; Gonzalez-Nilo, Fernando; Latorre, Ramon. Dissection of the components for PIP 2 activation and thermosensation in TRP channels. Proceedings of the National Academy of Sciences. 2007-06-12, 104 (24). ISSN 0027-8424. PMC 1891241 . PMID 17548815. doi:10.1073/pnas.0703420104 （英语）.
^ Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. October 1997, 389 (6653): 816–24. PMID 9349813. doi:10.1038/39807.
^ Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA. The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Genomics. August 2001, 76 (1-3): 14–20. PMID 11549313. doi:10.1006/geno.2001.6582.
^ Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol. Rev. December 2005, 57 (4): 427–50. PMID 16382100. doi:10.1124/pr.57.4.6.
^ Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, Chandran P, Gomtsyan A, Brown B, Bayburt EK, Marsh K, Bianchi B, McDonald H, Niforatos W, Neelands TR, Moreland RB, Decker MW, Lee CH, Sullivan JP, Faltynek CR. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J. Neurosci. 2006, 26 (37): 9385–93. PMID 16971522. doi:10.1523/JNEUROSCI.1246-06.2006.
^ Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De Petrocellis L, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (12): 8400–5. PMID 12060783. doi:10.1073/pnas.122196999.

[pmid17548815-1] Brauchi, Sebastian; Orta, Gerardo; Mascayano, Carolina; Salazar, Marcelo; Raddatz, Natalia; Urbina, Hector; Rosenmann, Eduardo; Gonzalez-Nilo, Fernando; Latorre, Ramon. Dissection of the components for PIP 2 activation and thermosensation in TRP channels. Proceedings of the National Academy of Sciences. 2007-06-12, 104 (24). ISSN 0027-8424. PMC 1891241 . PMID 17548815. doi:10.1073/pnas.0703420104 （英语）.

[pmid9349813-2] Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. October 1997, 389 (6653): 816–24. PMID 9349813. doi:10.1038/39807.

[pmid11549313-3] Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA. The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Genomics. August 2001, 76 (1-3): 14–20. PMID 11549313. doi:10.1006/geno.2001.6582.

[pmid16382100-4] Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol. Rev. December 2005, 57 (4): 427–50. PMID 16382100. doi:10.1124/pr.57.4.6.

[pmid16971522-5] Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, Chandran P, Gomtsyan A, Brown B, Bayburt EK, Marsh K, Bianchi B, McDonald H, Niforatos W, Neelands TR, Moreland RB, Decker MW, Lee CH, Sullivan JP, Faltynek CR. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J. Neurosci. 2006, 26 (37): 9385–93. PMID 16971522. doi:10.1523/JNEUROSCI.1246-06.2006.

[pmid12060783-6] Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De Petrocellis L, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (12): 8400–5. PMID 12060783. doi:10.1073/pnas.122196999.

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TRPV1

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