TRPV1是指“瞬态感受器电位阳离子通道,子类V,成员1”(transient receptor potential cation channel, subfamily V, member 1),该通道是一个蛋白质,在人类基因中由TRPV1基因所编码[2][3]。这一通道属于一种离子通道,是瞬态电压感受器族中的一员,属于TRPV组(即瞬态感受器电位阳离子通道,子类V)[4]。
TRPV1是一个配体门控非选择性阳离子通道,可以被各种外因性及内因性的物理及化学刺激所激发,例如:温度超过43 °C、pH值低(酸性环境)、内源性大麻素花生四烯酸乙醇胺、N-花生四烯酰基多巴胺以及辣椒素(辣椒的有效成分)。这一通道被发现存在于中枢神经系统及末梢神经系统上,并且涉及痛觉的传递和调制,以及整合各种同疼痛信息[5][6]。
- ^ Brauchi, Sebastian; Orta, Gerardo; Mascayano, Carolina; Salazar, Marcelo; Raddatz, Natalia; Urbina, Hector; Rosenmann, Eduardo; Gonzalez-Nilo, Fernando; Latorre, Ramon. Dissection of the components for PIP 2 activation and thermosensation in TRP channels. Proceedings of the National Academy of Sciences. 2007-06-12, 104 (24). ISSN 0027-8424. PMC 1891241
. PMID 17548815. doi:10.1073/pnas.0703420104 (英语).
- ^ Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. October 1997, 389 (6653): 816–24. PMID 9349813. doi:10.1038/39807.
- ^ Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA. The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Genomics. August 2001, 76 (1-3): 14–20. PMID 11549313. doi:10.1006/geno.2001.6582.
- ^ Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol. Rev. December 2005, 57 (4): 427–50. PMID 16382100. doi:10.1124/pr.57.4.6.
- ^ Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, Chandran P, Gomtsyan A, Brown B, Bayburt EK, Marsh K, Bianchi B, McDonald H, Niforatos W, Neelands TR, Moreland RB, Decker MW, Lee CH, Sullivan JP, Faltynek CR. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J. Neurosci. 2006, 26 (37): 9385–93. PMID 16971522. doi:10.1523/JNEUROSCI.1246-06.2006.
- ^ Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De Petrocellis L, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (12): 8400–5. PMID 12060783. doi:10.1073/pnas.122196999.